FABRICATION OF NICKEL SELENIDE NANOSTRUCTURE MODIFIED ELECTRODE FOR THE DETECTION OF DRUG MOLECULE.

Abstract

INTRODUCTION: The detection and analysis of drug molecule plays an important role in various fields including pharmaceutical research, clinical diagnostics and forensic analysis. The field of nanotechnology for drug detection is newly developing due its unique properties. The nickel selenide nanoparticle is a binary compound that has remarkable physicochemical properties and potential applications in various fields.

AIM: The aim of the study was to fabricate the nickel selenide nanoparticle and sensing of the drug using the nanoparticle.

MATERIALS AND METHODS: To 0.09M of Selenium 0.1M of Sodium borohydride was added in double distilled water.This solution was stirred for  3 hours and a black color solution was obtained . To this 0.07M of Nickel Nitrate was added and stirred for 1 hour .This mixture was left  in the centrifuge for 24 hours at 180℃ .It was then cooled  at room temperature and  dried ethanol was added to it and the nanoparticle powder was obtained .With this nanoparticle powder further drug sensing was carried out.

RESULTS: Basic analysis for the confirmation of material was done and it was found that the nickel selenide is pure crystalline in nature.FE SEM analysis showed that selenium particle were found like a layer on a sphere .The drug sensed was Paracetamol which was done using a modified electrode ,it was found to be active at pH-7.

DISCUSSION: Paracetamol is the most commonly used drug .The detection of Paracetamol using nickel selenide was highly stable.Nickel Selenide proved to be efficient in drug detection due to its morphological features .It had good catalytic activity ,good electrical conductivity and stability .

CONCLUSION: This study proves that the Nickel Selenide nanoparticles  were highly efficient in the detection of paracetamol ,due to their sensing ability and stability.